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Aberrant or a sustained activation of
2024-05-18
Aberrant or a sustained activation of AhR signaling pathway, triggered by exogenous toxic ligands such as dioxins, PAHs or polychlorinated biphenyls (PCBs), is a well-described biological process engaged during tumor initiation and/or promotion in various tissues (e.g. liver, lung, skin)(reviewed in
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To confirm a role of
2024-05-18
To confirm a role of OCT3 in corticosterone-induced potentiation of cocaine-primed reinstatement, we examined the interaction of corticosterone and cocaine in the reinstatement of cocaine conditioned place preference (CPP) in wild type mice, and transgenic OCT3-deficient mice. These mice express a t
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Active SI behavior was dose
2024-05-18
Active SI behavior was dose-dependently affected by PACAP treatment (F3,25 = 14.42, p CEP-32496 receptor 1 week later (F3,20 = 8.93, p hypothesis that PACAP causes disruptions in posterror adjustments that are similar to disruptions seen in humans with depression.
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To understand the kinase selectivity profile of this series
2024-05-18
To understand the kinase selectivity profile of this series, Ezatiostat hydrochloride australia , as a representative analog from this series, was profiled against 216 purified protein kinases representing the tyrosine and serine/threonine kinase families using an in-house Caliper EZ Reader mobilit
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br lipoxygenase pathway in brain aging and
2024-05-18
5-lipoxygenase pathway in TAME mg aging and alzheimer’s disease 5LO is found throughout the central nervous system, in both neuron and glia cells (Farias et al., 2007). However, its expression levels are highest in the cortex and hippocampus areas, two regions that are particularly vulnerable to
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On another hand pyrazoles are widely found as the
2024-05-18
On another hand, pyrazoles, are widely found as the core structure in a large variety of compounds of great biological and pharmaceutical value exhibiting anti-HCV [11], antitumor [12], cytotoxic[13], and antioxidant activities [14]. Finally, 1,2,3-triazoles have attracted the interest of medicinal
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To maintain ATP levels postmortem muscle
2024-05-18
To maintain ATP levels, postmortem muscle mobilizes its glycogen reserves to yield CT-99021 synthesis 6-phsphate that proceeds through glycolysis. Glycogen degradation was affected by the interaction between treatment and time (P 240min from the initiation of the experiment. We expected that if myos
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As previously mentioned when hypoxia treated cells become
2024-05-18
As previously mentioned when hypoxia-treated cells become re-oxygenated they sustain a significant amount of DNA damage which has been attributed to the formation of reactive oxygen species . This finding represents more than just an interesting in vitro phenomenon as within a tumor, cells have been
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Wound healing without blastema formation causes partial rest
2024-05-18
Wound healing without blastema formation causes partial restoration of lost tissue, and gives rise to fibrotic scars. Healing by fibrotic scarring rather than by regeneration leads to tissue dysfunction, and can place a huge burden for the health of the animal [4]. Therefore, understanding the molec
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br Material and methods br Results
2024-05-17
Material and methods Results Discussion Aminopeptidase N is a transmembrane protease present in a wide variety of human tissues and cell types (endothelial, epithelial, fibroblast, leukocyte). APN expression is dysregulated in inflammatory diseases as well as in solid and hematologic tumors
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About this report Alzheimer s Disease Facts and Figures
2024-05-17
About this report 2018 Alzheimer's Disease Facts and Figures is a statistical resource for U.S. data related to Alzheimer's disease, the most common cause of dementia. Background and context for interpreting the data are contained in the Overview. Additional sections address prevalence, mortality a
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br Impact of global AHR deficiency on diet induced
2024-05-17
Impact of global AHR deficiency on diet-induced obesity Two subsequent studies in which AHR function was affected at the whole animal level corroborated the role of AHR in dietary obesity. Xu et al. [14] showed that on a high-fat diet, both AHR-deficient Ahr−/− and hemizygous Ahr+/− mice gained s
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In chicken ovary the adiponectin gene was found
2024-05-17
In chicken ovary, the adiponectin gene was found to be mainly expressed in theca cells and is suggested to exert a paracrine or autocrine effect on ovarian steroidogenesis (Chabrolle et al., 2007). A limited number of studies have revealed the effect of adiponectin on ovarian steroidogenesis or its
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In the isolated right atrium
2024-05-17
In the isolated right atrium, activation of muscarinic receptors and adenosine receptors may block the generation of action potentials in the sinoatrial node, inducing cardiac arrest (Fig. 1, Fig. 2, Fig. 3, Fig. 4, Fig. 5) (Camara et al., 2015, Campbell et al., 1989). Physiologically, this conditio
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Although the role of mossy fiber
2024-05-17
Although the role of mossy fiber sprouting in epileptogenesis has been challenged (Elmer et al., 1997, Nissinen et al., 2001), in addition to astrogliosis, mossy fiber sprouting is one of the characteristic histopathological findings in TLE (Kharatishvili et al., 2006, Pitkanen et al., 2007, Represa