• Significantly elevated levels of DNA damage

  2019-07-18

  

  Significantly elevated levels of DNA damage observed in peripheral blood of tea garden women workers indicate the occupational exposure. The same was observed in cholinesterase activities, which detected lower activity in the exposed group compared to non-exposed. Large volumes of pesticides are use

• Alisol B 23-acetate Consistent with a clear separation of bi

  2019-07-18

  

  Consistent with a clear separation of biological function between ARISC and BRISC in cells, mutations in BRCC36 and Abraxas are prevalent in cancer genomes whereas mutations in KIAA0157 are rare. A survey of the Catalogue of Somatic Mutations in Cancer (COSMIC) consortium, revealed that to date, 37

• N acetylation by N acetyltransferase NAT is an important met

  2019-07-18

  

  N-acetylation by N-acetyltransferase (NAT) is an important metabolic pathway for some substances, and there are 2 functional NAT isoforms in humans—NAT1 and NAT2. Studies of etamicastat in healthy subjects showed an extensive N-acetylation of etamicastat to the inactive metabolite BIA 5-961, and a l

• Introduction Angiotensin II Ang II and

  2019-07-18

  

  Introduction Angiotensin II (Ang II) and Endothelin 1 (ET-1) are potent vasoconstrictive peptides recognized as key players in many cardiovascular diseases [1]. Cardiac hypertrophy, ischemic arrhythmia, and stroke have been associated to an overstimulation of the angiotensin II type 1 (AT1) recepto

• br Discussion Variable estradiol effects on cell

  2019-07-18

  

  Discussion Variable estradiol effects on cell proliferation have been reported according to animal species, tissues, and type of estrogen receptor [16,21,22,[29], [30], [31]]. In the kidney, 17βE was found to increase [3H]-thymidine incorporation in primary rabbit kidney proximal tubule Palifosfa

• Finally naringin and hesperidin have different

  2019-07-18

  

  Finally, naringin and hesperidin have different glycosidic moieties (neohesperidose α-1,2 and rutinose α-1,6 respectively), bound in the same C7 position on the A ring of the flavonoid. The higher value of k/KM of RHA-Phis towards the former substrate suggests that the enzyme shows a preferential hy

• Despite many studies having demonstrated the importance of c

  2019-07-18

  

  Despite many studies having demonstrated the importance of connexin43 (Cx43), the most abundant connexin in bone cells, for bone development and turnover during the last decade [27], little is currently known about GJIC and Cx43 in primary bone tumors. In this report, we analyzed the specific role o

• Several reasons may explain that

  2019-07-17

  

  Several reasons may explain that other studies using PDE-5-Is yielded negative or contradictory results [30], [31], [32]. Lee [30] applied 50mg sildenafil to seven patients with liver cirrhosis. NO and cGMP in the hepatic CEP-18770 significantly increased, hepatic and pulmonary resistance decreased

• br DUBs in regulation of

  2019-07-17

  

  DUBs in regulation of critical steps in tumor metastasis Tumor metastasis comprises a complicated series of biological processes in terms of the invasion-metastasis cascade that requires cancer carboxypeptidase a to (1) migrate and invade from the origin sites through the extracellular matrix (E

• This hydrophobic biphenyl tail gave

  2019-07-17

  

  This hydrophobic biphenyl tail gave good binding affinity for human DHODH enzyme (IC Glutathione (GSH/GSSG/Total) Fluorometric Assay Kit was found to be the main metabolite in human microsomes and it was 100-fold less active against hDHODH than the ester. In an attempt to identify the specific non

• Our current understanding of nucleotide metabolism in has ma

  2019-07-17

  

  Our current understanding of nucleotide metabolism in has made it possible to identify numerous proteins which serve essential roles in the life cycle of the parasite. One such protein is thymidylate synthase-dihydrofolate reductase (TS-DHFR), a bifunctional enzyme which is necessary for the produc

• The early serologic response of infants to infection with

  2019-07-17

  

  The early serologic response of infants to infection with HIV-1 is obscured by the presence of transplacentally acquired maternal HIV antibody. However, the HIV rosmarinic acid produced in vitro by peripheral blood from infants has been studied (Pollack et al., 1993) and it has been shown that neona

• br Results and discussion br Conclusion In

  2019-07-17

  

  Results and discussion Conclusion In this research, several anti-inflammatory agents with pyrazolo[3,4-d]pyrimidine cores were synthesized. Such choice of large core than regular pyrazole was valid as a proper modification. That most of the prepared compounds showed excellent AI activity. In a

• DDR is characterized by an N

  2019-07-16

  

  DDR2 is characterized by an N-terminal discoidin domain and a C-terminal kinase domain [7]. Characteristics of DDR1, which is a homologue of DDR2, have been extensively investigated in terms of expression level in cancer tissues and biological functions in normal and cancer cell conditions, but char

• The CysLT receptor antagonist BayCysLT RA significantly

  2019-07-16

  

  The CysLT2 receptor antagonist BayCysLT2RA significantly suppressed multiple antigen challenge-induced infiltration of eosinophils and mononuclear corticotropin releasing factor into the lung, indicating that CysLT2 receptor activation is involved in leukocyte migration. In contrast to the present

16451 records 1027/1097 page Previous Next First page 上5页 10261027102810291030 下5页 Last page