• We not only found that

  2019-07-09

  

  We not only found that the ISR leads to attenuation of conventional cap-dependent translation with no change in RAN translation of the G4C2 expanded repeat, but also that GA translation from the expanded repeat (but not from 5 G4C2 repeats, perhaps because the protein product does not aggregate) is

• ACSF E protein expressed in a plasmid encoding codon optimiz

  2019-07-09

  

  E1 protein expressed in a plasmid encoding codon-optimized canine oral papillomavirus (COPV) led to therapeutic immunization of COPV-infected Beagle dogs [25], [26], which was better than that achieved with plasmids encoding E2 or E7 COPV. Moreover, E1 and E2 from cottontail rabbit papillomavirus (C

• Kuo et al Have shown that DAPK function

  2019-07-09

  

  Kuo et al. (2006) Have shown that DAPK1 function in inhibiting microtubule (MT) assembly is through the activation of microtubule affinity-regulating kinases (MARK)/PAR-1 family kinases MARK1/2, which destabilize MT by phosphorylating tau and related MAP2/4. This relation with DAPK1 has demonstrated

• MK-8776 br Materials and methods br Acknowledgements SD was

  2019-07-09

  

  Materials and methods Acknowledgements SD was supported by a pre-doctoral research fellowship from the Flanders Agency for Innovation and Entrepreneurship (VLAIO-Flanders, Belgium). YB is supported by a postdoctoral fellowship from Research Foundation Flanders (FWO, Belgium). We thank Isabelle

• The androgen receptor AR is a

  2019-07-09

  

  The androgen receptor (AR) is a steroid hormone receptor that plays a crucial role in the normal development of male reproductive tissues, and its high expression and/or relaxation of its regulation are strongly implicated in prostate cancer (PCa) [11]. Androgen binding induces conformational change

• The best characterized APC C

  2019-07-08

  

  The best-characterized APC/C substrates are recruited via various linear motifs (e.g., D boxes, KEN boxes, and ABBA motifs) that serve as degrons, binding to distinct regions of the β-propeller domain of a coactivator (Figure 1, Figure 3B) (reviewed in [44]). In addition, D boxes also simultaneously

• We also note that though the deletion of the

  2019-07-08

  

  We also note that though the Lubiprostone of the N-terminus in Ube2E1∆N46 or the mutations in Ube2E16KtoR enhanced their activity compared to the wild type, it failed to match Ube2D2 (Fig. 1). We concluded this difference to be multi-factorial as none of the Ube2E1∆N46 point mutants involving “Ub b

• Dipeptidyl peptidase inhibitors DPP is or gliptins stimulate

  2019-07-08

  

  Dipeptidyl peptidase-4 inhibitors (DPP-4is or gliptins) stimulate both post-meal insulin secretion and inhibit Ouabain structure secretion in a glucose-dependent manner, rendering the risk of hypoglycaemia minimal [10]. They are weight-neutral or may even induce slight weight loss. Their good effic

• In summary we hypothesize that targeting the A R

  2019-07-08

  

  In summary, we hypothesize that targeting the A1R–D1R heterotetramer with heteromer-selective drugs might improve safety and efficacy of the pharmacological therapy for RLS and other motor diseases, resulting in fewer side effects than classical drugs developed for targeting monomeric A1R or D1R.

• Here we explored the relative

  2019-07-08

  

  Here we explored the relative contribution of D1-like and D2-like receptor subtypes in the control of glutamate release, as well as their pharmacological properties and their interactions modulating the release. The pharmacological parameters (EC50 and Emax) of dopamine for the different types of re

• Several reports have exploited the application of

  2019-07-08

  

  Several reports , , , , have exploited the application of HRM for detecting differentially methylated DNA. Even though DNA methylation analysis by HRM cannot determine the methylation status of individual CpGs, it does provide a robust and inexpensive method to differentiate DNA based on the overal

• Although the ferromagnetic particles and T DNA ligase on the

  2019-07-08

  

  Although the ferromagnetic particles and T4 PPY A molecular on the particles were heated by the ac magnetic field, the average temperature of the reaction solution as a whole was kept suitably low for the annealing of DNA ends (16°C). Indeed, no appreciable increase in the temperature of the reacti

• br Other Alterations in Triglyceride Metabolism in

  2019-07-08

  

  Other Alterations in Triglyceride Metabolism in DGAT-Deficient Mice Consistent with the enzyme\'s ubiquitous expression pattern, DGAT deficiency also altered triglyceride metabolism in other tissues. For example, postpartum Dgat−/− female mice were unable to nurse their young owing to an absence

• The aniline R group was extensively

  2019-07-08

  

  The aniline R2 group was extensively explored and a large variety of substitution was tolerated at several positions on the aryl ring (). Notably, substitution at the 3-position often gave increased potency. Increasing lipophilic bulk at this position gave increasing potency within an ether series (

• br Phylogenetic analysis KSTDs have rather diverse amino aci

  2019-07-08

  

  Phylogenetic analysis — Δ1-KSTDs have rather diverse amino AMG232 structure sequences. A sequence distance analysis using the program MEGA6 [75] of all currently biochemically characterized Δ1-KSTDs yielded a largest p-distance [76] of 0.67 (on a scale of 0-1) for the Δ1-KSTDs from the actinobacte

16379 records 1028/1092 page Previous Next First page 上5页 10261027102810291030 下5页 Last page