• Pilsicainide might increase hERG proteins

  2019-06-01

  

  Pilsicainide might increase hERG proteins via facilitating the transcription of hERG from DNA to RNA or the translation of hERG RNA into hERG protein. Qualitative RT-PCR demonstrated the absence of an increase in hERG mRNA expression levels after pilsicainide treatment (Supplemental Fig. S2), indica

• Economic sanctions have exacerbated the brutality of this co

  2019-05-31

  

  Economic sanctions have exacerbated the brutality of this conflict many-fold, removing any prospects for peace and reconciliation. We need some reality to gauge their manifold effects before Syria descends into another Iraq, the devastating health consequences of which were well documented. Syria u

• More than structural haemoglobin variants

  2019-05-31

  

  More than 900 structural haemoglobin variants have been described. Of these more than 100 show high oxygen affinity [2]. Erythrocytosis caused by Hb Ypsilanti was first described in 1967 [3], and the mutation results in substitution of amino Mifepristone (β99 Asp→Tyr) involved in the stability of th

• calpain inhibitor Complete surgical resection of the tumor a

  2019-05-31

  

  Complete surgical resection of the tumor at the time of diagnosis is essential towards effective management of PPB. Unfortunately, a large cohort of patients present with an advance stage of disease where the tumor has grown to such an extent to invade surrounding vital structures, hindering the com

• Many studies over the past years

  2019-05-31

  

  Many studies over the past 20 years have shown the potential of urinary markers in the detection of the presence of bone metastases [3–11], the use of urinary markers for its prognostic value in bone disease [2,4,12–20], as well as directing therapy for bone metastases patients [2,6,12–18,21–25]. T

• Our results are consistent with previous findings in other m

  2019-05-31

  

  Our results are consistent with previous findings in other malignancies. Functional assays revealed that ectopic expression of UCA1 promoted cell proliferation and/or reduced cell apoptosis in non-small cell lung cancer [19], breast cancer [18], colorectal cancer [28], and renal cell carcinoma [23]

• Introduction The Yoga My Heart Study was a single

  2019-05-31

  

  Introduction The Yoga My Heart Study was a single center study that brought to light the therapeutic impact a noninvasive, medication-free intervention has on a costly disease. Atrial fibrillation (AF) is a common cardiac arrhythmia that affects two to three million people worldwide. It is associat

• A lo largo de todo

  2019-05-30

  

  A lo largo de todo el siglo abundan las obras literarias incitadas por la búsqueda y promoción de la originalidad del continente; en el terreno lírico, la del argentino Juan María Gutiérrez (1809-1878) se erige como una de las más genuinas expresiones de esta tradición americanista. No por mero az

• Es un hecho innegable que la

  2019-05-30

  

  Es un hecho innegable que la descripción que Servando Teresa de Mier plasma en sus Memorias (escritas en las cárceles inquisitoriales de Nueva España entre 1818 y 1820) sobre su estadía forzada en Europa por más de veinte años presenta exageraciones sobre el castigo que la Inquisición española le im

• Ethiopia is faced with challenging

  2019-05-30

  

  Ethiopia is faced with challenging circumstances. It is a low-income country, with a gross domestic product estimated by the International Monetary Fund at US$570 per person in 2014, and 66% of the purchase Cyanine3.5 alkyne living on less than US$2 per day in 2011—rates that are even lower than th

• There are a number of reasons for this disparity people

  2019-05-29

  

  There are a number of reasons for this disparity: people with disabilities are disproportionately poor, lacking in access to education and employment, and excluded from social networks. Health-care facilities, equipment, and transportation are often inaccessible. But another significant factor is th

• In a study of the atrial pacing preference

  2019-05-29

  

  In a study of the atrial pacing preference (APP) algorithm, Ogawa et al. [12] randomly programmed pacemakers as APP OFF and APP ON at 3 different settings (8, 16, and 33 cycles). The authors found that the most effective setting differed according to the patient and thus concluded that this therapy

• On the basis of this mechanism the prolonged

  2019-05-29

  

  On the basis of this mechanism, the prolonged RR interval with the patient\'s symptoms was likely a reflection of the progression of the AV block with an underlying first-degree AV block. Despite a first-degree AV block (420ms) during the short RP rhythm, a short PR interval (160ms) was observed wit

• pitavastatin En ese encuentro de intereses entre los

  2019-05-29

  

  En ese encuentro de intereses entre los distintos grupos, bien sea por dominar el territorio, o por imponer la fuerza, o bien por controlar el negocio del narcotráfico, la población queda expuesta y vulnerable. Los ataques entre unos y otros tienen serias repercusiones sobre los poblados “las accion

• Otra cuesti n que debi afrontar la

  2019-05-29

  

  Otra cuestión que debió afrontar la política exterior argentina fue la necesidad de recuperar la inserción del país en Latinoamérica. En el abordaje de esta cuestión, como en la referida dhpg las situaciones de dependencia, la política exterior contó con un contexto internacional muy permisivo, grac

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