• br Conclusion Pu erh extracts

  2018-11-06

  

  Conclusion Pu-erh extracts showed a strong protection effect against the hepatic damage by oxidative stress. The protection mechanism of Pu-erh extracts is confirmed in the study via the activation of the hepatic antioxidant system and the reversal of lipid peroxidation. In addition, Pu-erh tea e

• anti fungal br Ketone bodies in a cell

  2018-11-06

  

  Ketone bodies in a cell culture model of AD Neuroprotective properties of ketone bodies have been investigated in cell cultures. A proteolytic fragment of the β chain of amyloid precursor protein, Aβ1–42, is toxic to hippocampal cells. The exposure of 6-day cultured hippocampal neurons from 18-da

• The identification of new stem cell markers characteristic o

  2018-11-06

  

  The identification of new stem cell markers characteristic of a phenotypic subset or experimental state remains a major 69 9 research goal. Researchers may wish to assess the uniqueness of an expression profile before embarking on experiments that rely on a reporter gene or antibody to select for a

• Numerous published reports have examined the potential of

  2018-11-06

  

  Numerous published reports have examined the potential of differentiated cell types derived from mouse and human ESCs to repair nonhuman target organs in intact animals. Recent studies, however, have yielded both encouragement and caution, with restoration of function evident to some degree in many

• The use of a novel Pax Venus

  2018-11-06

  

  The use of a novel Pax9Venus reporter PSC line allowed the purification of PSC-derived Pax9+ AFE for molecular analysis and enabled the comparison to embryonic Pax9+ AFE. The expression of several pharyngeal endoderm transcription factors in PSC-derived Pax9+ AFE suggests that these EZ Cap Reagent A

• hydroxycarboxylic acid receptors Chondrogenic differentiatio

  2018-11-06

  

  Chondrogenic differentiation in our model is affected by deregulation of LMNA, especially in PG-MSCs, as revealed by a lowered COL2/COL1 ratio and lower expression of COL2 and AGG as shown by real-time RT-PCR. While our findings do not completely agree with the results of the study by Scaffidi and M

• To test the efficiency of gene knockdown the

  2018-11-06

  

  To test the efficiency of gene knockdown, the ES cell lines expressing the shPU.1 constructs were differentiated into hematopoietic cells. The transcription factor PU.1 is not expressed in ES g protein coupled receptors at day 0 of differentiation and becomes expressed by day 9 when hematopoietic p

• br Acknowledgments br Introduction Two developmental

  2018-11-06

  

  Acknowledgments Introduction Two developmental processes take place during pre-implantation in the development of mammalian embryos. The outer ubiquitin e3 ligase of the morula differentiate into a trophoectoderm (TE) lineage, whereas the inside cells become the inner cell mass (ICM). Further

• orexin The FRGN strain developed herein is suitable for

  2018-11-06

  

  The FRGN strain developed herein is suitable for hematopoietic reconstitution and in addition to this has some other advantages over our originally reported FRG KO on the C57BL6 strain (Azuma et al., 2007). While the final percentages of highly reconstituted (>80%) mice did not differ significantly

• br Materials and methods br Results br Discussion

  2018-11-06

  

  Materials and methods Results Discussion Strategies aiming at controlled divergence of ASCs to specific differentiated cell types essentially rely on prolonged culture in the presence of specific sets of growth factors and/or matrix proteins (Zuk et al., 2001). Specific culture conditions w

• In contrast to the variable descriptions of heart regenerati

  2018-11-06

  

  In shk to the variable descriptions of heart regeneration in amphibians, zebrafish can regenerate following multiple types of cardiac injury including ventricular resection, cryoinjury and genetic cardiomyocyte ablation (Gonzalez-Rosa et al., 2011; Poss et al., 2002; Wang et al., 2011). Cardiac inj

• The intestinal epithelium is a particularly attractive biolo

  2018-11-06

  

  The intestinal epithelium is a particularly attractive biological adult model to study epigenetic mechanisms driving differentiation in vivo. In the intestinal epithelium, two populations of SC have already been described and isolated (Lgr5+ and Bmi1+ cells; Barker et al., 2007; Sangiorgi & Capecchi

• br DNA fingerprinting analysis The

  2018-11-06

  

  DNA fingerprinting analysis The target regions of genomic DNA were amplified by Polymerase chain reaction (PCR). The PCR was carried out using a Thermocycler type PTC100 (MJ Research Inc) for 35cycles and each cycle contained 96°C for 30s, 56°C for 30s and 72°C for 30s. The following primer seque

• br Introduction The grafting of

  2018-11-06

  

  Introduction The grafting of cultured keratinocytes to promote regeneration represents one of the oldest clinical examples of stem cell therapy (Green, 2008). The skin constitutes an essential barrier between the living tissues of the body and the external environment, and skin tissues have evolv

• We next assessed how reflective the HDR editing

  2018-11-05

  

  We next assessed how reflective the HDR editing rates calculated via deep-sequencing were of actual editing rates. Hence, the CTS protocol was repeated for all seven variants independently, and approximately 250 clonal populations were then picked and analyzed via Sanger sequencing. We successfully

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