• Partial cleavage of CXCL at the N terminus by distinct

  2018-10-24

  

  Partial cleavage of CXCL12 at the N-terminus by distinct peptidases results in loss of chemotactic activity and impairment in CXCR4 receptor affinity (Cho et al., 2010; Delgado et al., 2001; Levesque et al., 2003). The proteolytic cleavage of CXCL12 by matrix metalloproteinase 2 and 9 (MMP-2 and 9)

• br Experimental Procedures br Author Contributions

  2018-10-24

  

  Experimental Procedures Author Contributions Acknowledgments Introduction Induced pluripotent stem leukotriene receptor agonist (iPSCs) have similar properties as embryonic stem cells (ESCs), such as self-renewal and differentiation capacity (Park et al., 2008c; Takahashi and Yamanaka,

• Introduction Human pluripotent stem cells hPSCs i e human em

  2018-10-24

  

  Introduction Human pluripotent stem h2 receptor antagonist (hPSCs), i.e., human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs), can give rise to functional neurons (reviewed in Gage and Temple, 2013). Human peripheral neurons are difficult to differentiate, but a re

• We sought to determine whether

  2018-10-24

  

  We sought to determine whether T cell-derived iPSCs (TiPSCs) could be used to analyze neurological diseases. Several issues regarding the utilization of TiPSCs in neurological studies remain unresolved. First, previous studies indicated that each iPSC clone retains an epigenetic memory relating to t

• The reprogramming of somatic cells was originally demonstrat

  2018-10-24

  

  The reprogramming of somatic prolyl hydroxylase was originally demonstrated by producing cloned frogs using somatic cell nuclear transfer (SCNT) into Xenopus oocytes (Gurdon et al., 1958). Reprogramming of mammalian somatic cells has also been achieved using SCNT into oocytes, including those of mi

• DENV has also been shown

  2018-10-24

  

  DENV has also been shown to counteract IFN signaling in the infected cells, mainly through the expression of NS5 and NS4B (Munoz-Jordan et al., 2005; Ashour et al., 2009; Morrison et al., 2013). We indeed observed lessened ISG induction in the infected dna pk but not in the uninfected cells in the

• Elevated SHH signaling in the dorsal

  2018-10-24

  

  Elevated SHH signaling in the dorsal V-SVZ regulates the production of oligodendrocyte progenitor cells in the corpus callosum while SHH signaling in the ventral V-SVZ controls the production of specific neuron subtypes destined for the OB (Tong et al., 2015). We previously observed that PTC deletio

• The naive to lineage primed transition

  2018-10-24

  

  The naive to lineage primed transition was proposed as a gradual continuum of pluripotent states with distinct functional and transcriptional signatures and biases (Tesar, 2016). Several stem cell types with different degrees of pluripotency can be established under artificial culture conditions (Wu

• sgk inhibitor The widespread hope for a new era of

  2018-10-24

  

  The widespread hope for a new era of prevention and treatment for chronic neurological disorders, such as stroke, Alzheimer\'s disease, and Parkinson\'s disease, will likely depend on the discovery of new CNS drugs. However, currently over 99% of candidate CNS drugs fail in clinical tests because of

• In the presence of calreticulin a

  2018-10-24

  

  In the presence of calreticulin, a cadherin switch occurs between E- and N-cadherins during the course of cardiomyocyte differentiation. This is exhibited by a decrease in E-cadherin abundance with a progressive increase in (and replacement by) N-cadherin. The presence of N-cadherin at the cell surf

• Here using hNPCs derived from RTT patient iPSCs as

  2018-10-24

  

  Here, using hNPCs derived from RTT patient iPSCs as an example, we have shown that our method of hypoxia-mediated rapid astrocytic differentiation of hNPCs can be applied to functional analysis of patient-derived astrocytes. We revealed that MECP2 MT astrocytes diminish the soma size, neurite outgro

• The BM lin CD CD population significantly overlaps with LSK

  2018-10-24

  

  The BM lin−CD201+CD27+ population significantly overlaps with LSK nrf2 keap1 in B6 mice and consists of early HSPCs. Lin−CD201+CD27+ cells have been proposed for alternative HSPC identification in mouse strains (e.g., BALB/c or NOD strains) or under stress conditions, which lack a distinct LSK immu

• hmg-coa reductase The thermal field emission flux becomes su

  2018-10-24

  

  The thermal field emission flux becomes substantial as the surface temperature reaches a certain value, namely The calculations show that the surface roughness reduces the effect of hmg-coa reductase emission, and in fact at a sufficiently high degree of roughness (∼0.8) emission can be neglecte

• Approaches in the literature The literature on sustainabilit

  2018-10-23

  

  Approaches in the literature The literature on sustainability of fiscal policy that applies the temporal government budget constraint started with the seminal article by Hamilton and Flavin (1986) who test whether the budget deficit path follows a stationary stochastic process. The rejection of the

• This study demonstrates the current and important

  2018-10-23

  

  This study demonstrates the current and important trend of incorporating a multidimensional approach to assessing interactive illness risk and progression processes in youth at confirmed high-risk (). However, the interpretation of the specific findings should be taken as preliminary given several l

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