• Olanzapine has been reported to attenuate insulin secretion

  2021-11-17

  

  Olanzapine has been reported to attenuate insulin secretion, cause insulin resistance (Chintoh et al., 2008) and reduce whole body carbohydrate oxidation (Klingerman et al., 2014). However, a blunting of these effects in Gcgr−/− mice would not appear to explain the protection against olanzapine-indu

• In mammals the primary cilium is

  2021-11-17

  

  In mammals, the primary cilium is considered a hub for signal transduction. The cilium has previous been associated with transduction of several pathways including Wnt (Corbit et al., 2008, McDermott et al., 2010, Tran et al., 2014), PDGF (Clement et al., 2013, Schneider et al., 2010, Schneider et a

• GPR which is also known as FFA receptor FFAR or

  2021-11-17

  

  GPR40, which is also known as FFA receptor 1 (FFAR1 or FFA1), was identified as an orphan receptor in the search for novel human galanin receptor (GALR) subtypes in 1997. Using reverse pharmacology approaches measuring calcium transients, GPR40 were deorphanized and characterized as being activated

• Because AM had limited efficacy on

  2021-11-17

  

  Because (AM-3189) had limited efficacy on rodent GPR40, we used two rodent models expressing human GPR40 to demonstrate efficacy of (AM-3189). First, we used human islet transplanted nude mice. In this model, endogenous pancreatic β-cells were ablated using streptozotocin, and mice were rescued to e

• In addition the interplay of membrane curvature induced tens

  2021-11-17

  

  In addition the interplay of membrane curvature induced tension at the fusion pore and Iberin induced tension across the PM seems to be a worthwhile target for investigation. The roles of dynamin and myosin II and especially their spatial and temporal dynamics during activity warrant further resear

• This connection is supported by studies in the

  2021-11-17

  

  This connection is supported by studies in the SIV macaque model of HIV, where treatment with methamphetamine, which greatly enhances CNS dopamine levels (Truong, 2005); increased cftr inhibitor viral load. Methamphetamine also increased expression of the HIV co-receptor CCR5 in CNS macrophages, th

• In comparison to the standard HPLC assay to detect LPV

  2021-11-17

  

  In comparison to the standard HPLC assay to detect LPV above or below 1,000 ng mL-1, the accuracy of the PIs-IC strip was 97.8 %, the sensitivity was 100% and the specificity was 97.1 %. This suggests that the PIs-IC strip test has the potential accurately to semi-quantify PI concentrations in plasm

• br Materials and methods br Results

  2021-11-17

  

  Materials and methods Results Discussion It has previously been reported that EZH2 plays a key role in the silencing of tumour suppressor genes through methylation of H3K27me3 in the promoter region of these genes in neuroblastoma [32], [40]. In this study, we show that EZH2 is aberrantly g

• Immunohistochemical analysis of sheep skin sections showed t

  2021-11-17

  

  Immunohistochemical analysis of sheep skin sections showed that sGC prtotein is expressed in the hair follicles with different location and abundance between white and black sheep skin (Fig. 6). In white sheep skin, Strong sGC positive signal was detected in the upper hair dermal papilla but no posi

• In order for cytokines to exert any

  2021-11-16

  

  In order for cytokines to exert any effect on the NSC population, they must first bind to specific receptors on the cell surface. Numerous pro- and anti-inflammatory cytokines are able to exert effects on the NSC population, including IL-1β through IL-1R1 and IL-1R2, TNFα through TNFR1 and TNFR2, IL

• The vast majority of clinical studies have shown that chroni

  2021-11-16

  

  The vast majority of clinical studies have shown that chronic administration of GLP-1R agonists frequently lowers SBP/DBP in diabetic humans, which is consistent with preclinical studies, though the reported reductions are not as potent as those observed in their animal counterparts. In contrast, ac

• br Conflict of interest br Introduction Since its discovery

  2021-11-16

  

  Conflict of interest Introduction Since its discovery in 1958 [1]the Ca2+-dependent K+ efflux in human red blood mixed-methods (RBC) (further referred to as the Gárdos effect) has been extensively studied (see 2, 3for review) and has been helpful in understanding the role of the Ca2+-activated

• On the other hand with the

  2021-11-16

  

  On the other hand, with the exception in muscle tissue, cGalR2 and cGalR2-L transcripts were also found to be widely distributed among the peripheral tissues at different levels (Fig. 2). The precise functions of cGalR2 and cGalR2-L in these peripheral tissues remain to be established, however, thei

• br Short Communication Lactococcus lactis is traditionally u

  2021-11-16

  

  Short Communication Lactococcus lactis is traditionally used as a starter culture in the production of fermented dairy food products, such as cheese, sour cream, and buttermilk (Cavanagh et al., 2015). Two main pathways of lactose uptake and metabolism have been described for L. lactis. In the fi

• adefovir There are limited studies on

  2021-11-16

  

  There are limited studies on antibody responses against HIV-1 integrase antigen. According to previous studies, almost 5 percent of individuals infected with HIV never raise anti-integrase adefovir (Rikhtegaran Tehrani et al., 2015; Chang et al., 1985). If this rate is identical in individuals infe

16462 records 562/1098 page Previous Next First page 上5页 561562563564565 下5页 Last page